Implanted neuronal stem cells generate neurons and synapses, becoming a functioning part of mouse brain
Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have grafted induced neuronal stem cells (iNSC) into the brains of mice, with long-term functionality and stability, for the first time. Six months after implantation, the new neurons, reprogrammed from skin cells, became fully and functionally integrated into the brain, creating synapses and glial cells.
This successful implantation of neurons raises hope for future therapies for neurodegenerative diseases, replacing sick neurons with healthy ones — in the brains of Parkinson’s disease patients, for example. However, “successes in human therapy are still a long way off,” cautioned principal investigator Prof. Jens Schwamborn.
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